Tags: Biostatistics
Computational Pharmacokinetics (Chapman & Hall/CRC Biostatistics Series) 1st Edition
TITLE : Computational Pharmacokinetics
(Chapman & Hall/CRC Biostatistics Series) 1st Edition
ISBN : 9781420060652
AUTHOR : Anders Kallen (Author)
PUBLISHER : Taylor
FORMAT: Hardcover
PAGES : 184
YEAR PUBLICATIONS : 2007
LANGUAGE: English
SUBJECT:
WEIGHT (KG): 0.3
CONDITION: Used - Like New
DESCRIPTION:
Being
that pharmacokinetics (PK) is the study of how the body handles various
substances, it is not surprising that PK plays an important role in the early
development of new drugs. However, the clinical research community widely
believes that mathematics in some way blurs the true meaning of PK.
Demonstrating that quite the opposite is true, Computational Pharmacokinetics
outlines the fundamental concepts and models of PK from a mathematical
perspective based on clinically relevant parameters.
After an introductory chapter, the book presents a noncompartmental approach to
PK and discusses the numerical analysis of PK data, including a description of
an absorption process through numerical deconvolution. The author then builds a
simple physiological model to better understand PK volumes and compares this
model to other methods. The book also introduces compartmental models,
discusses their limitations, and creates a general-purpose type of model. The
final chapter looks at the relationship between drug concentration and effect,
known as PK/pharmacodynamics (PD) modeling.
With both a solid discussion of theory and the use of practical examples, this
book will enable readers to thoroughly grasp the computational factors of PK
modeling.